Restoration of p53 function leads to tumour regression in vivo

  title={Restoration of p53 function leads to tumour regression in vivo},
  author={Andrea Ventura and David G Kirsch and Margaret E. Mclaughlin and David A Tuveson and Jan Grimm and Laura Lintault and Jamie L Newman and Elizabeth E. Reczek and Ralph Weissleder and Tyler 8 Jacks},
Tumorigenesis is a multi-step process that requires activation of oncogenes and inactivation of tumour suppressor genes. Mouse models of human cancers have recently demonstrated that continuous expression of a dominantly acting oncogene (for example, Hras, Kras and Myc) is often required for tumour maintenance; this phenotype is referred to as oncogene addiction. This concept has received clinical validation by the development of active anticancer drugs that specifically inhibit the function of… CONTINUE READING
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