Restoration of normal sperm characteristics in hypoprolactinemic infertile men treated with metoclopramide and exogenous human prolactin

  title={Restoration of normal sperm characteristics in hypoprolactinemic infertile men treated with metoclopramide and exogenous human prolactin},
  author={C. S. Ufearo and Orish Ebere Orisakwe},
  journal={Clinical Pharmacology \& Therapeutics},

Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism

The majority presented with normal semen quality based on the determination of the number of progressively motile spermatozoa and the data suggest reduced LH bioactivity in patients with pituitary insufficiency.

Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat.

Results show that S. chinensis and its single compound, gomisin N, are regulators of PRL production and may be candidates for treatment of hyperprolactinemia and prolactinoma.

An investigation of the effectiveness of testosterone implants in combination with the prolactin inhibitor quinagolide in the suppression of spermatogenesis in men.

Results show that inhibition of PRL does not to confer additional efficacy in spermatogenic suppression in men, and Q did not totally block PRL secretion in the subjects, possibly because testosterone replacement itself stimulated PRL by a direct action on the lactotroph, thus the effectiveness of dual inhibition of gonadotrophin and PRL could be fully investigated.

The role of prolactin in andrology: what is new?

There is significant evidence supporting the hypothesis that PRL could be a mirror of serotonin in the brain, and an association with anxiety or depressive symptoms has been found in men with sexual dysfunction and from the general European population.

Prolactin serum concentrations during aripiprazole treatment in youth.

With the increasing use of aripiprazole in the United States population, it is important that future research be conducted to explore the potential sequelae of subnormal PRL serum levels in children and adolescents.

Effect of diclofenac on semen quality: A review

Diclofenac appears to induce negative effects on both qualitative and quantitative measures of sperm; however, this conclusion requires confirmation by human studies.

A case of risperidone-induced priapism in a patient with glucose-6-phosphate dehydrogenase deficiency

A case of risperidone-induced priapism in a man with glucose-6-phosphate dehydrogenase (G6PD) deficiency is presented.

Plasma Concentration of Prolactin, Testosterone Might Be Associated with Brain Response to Visual Erotic Stimuli in Healthy Heterosexual Males

The results suggested sexual hormones in basal state may have their specific target regions or network associated with sexual response, and positively associated with brain activity of the bilateral supplementary motor area which related with motivational component of sexual behavior.

Aripiprazole-Induced Hypoprolactinemia in an Adult Male with First-Episode Psychosis.

A case of aripiprazole-induced hypoprolactinemia in an adult male with first-episode psychosis is reported, and the possible effects of abnormally low prolactin are discussed.

Preclinical risk assessment of drug‐induced hypo‐ and hyperprolactinemia

It is shown that classic hallmarks of hypo‐/hyperprolactinemia can be recognized in short‐ and long‐term rodent bioassays and taken together with human epidemiological evidence pertaining to the consequences of drug‐induced hypo-/hyper Prolactin signaling permit both an analysis of human relevance and an assessment of human risk.



Effects of experimentally-induced chronic hyperprolactinemia on testosterone and gonadotropin levels in male rats and mice.

In inbred CD-F rats and DBA/2J mice with chronic hyperprolactinemia induced by grafting 4 anterior pituitaries from adult females of the same strain under the kidney capsule, testicular and pituitary function was examined.

Prolactin, growth hormone, and luteinizing hormone in the maintenance of testicular luteinizing hormone receptors.

To elucidate further pituitary influence on testicular function, we studied the effect of PRL, GH, and LH alone or in various combinations on the maintenance of testicular LH receptor concentration

Modulation of prolactin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion by LHRH and bromocriptine (CB154) in the hypophysectomized pituitary-grafted male rat and its effect on testicular LH receptors and testosterone output.

LHRH treatment and the increased gonadotropin secretion caused by it, increase testis weight with an associated increase in LH binding and ability and the results suggest that small amounts of LHRH stimulated a greater and more prolonged increase in the levels of FSH than of LH.

Testicular LH binding in the hamster: modification by photoperiod and prolactin.

The results suggest that the mechanism by which PRL stimulates testicular function in hamsters with regressed gonads is through increased binding of endogenously produced LH.

Effect of prolactin and growth hormone on prolactin and LH receptors in the dwarf mouse.

The results suggest that lack of prolactin but not of GH retards sexual development in these mice, and treatment with prolact in partly counteracts this deficiency, and the effect may be mediated by the induction of hepatic and testicular prolACTin and LH receptors.

The MIF stain-preservation technic for the identification of intestinal protozoa.

Summary A simple, stain-preservative solution for intestinal protozoa is described. Its use permits busy clinical laboratories to achieve highly accurate stool diagnoses with far less time and