Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.

@article{Salehi2009RestorationON,
  title={Restoration of norepinephrine-modulated contextual memory in a mouse model of Down syndrome.},
  author={Ahmad Salehi and Mehrdad Faizi and D. Vargas Col{\'a}s and Janice S. Valletta and J. R. Campillo Laguna and Ryoko Takimoto-Kimura and Alexander Kleschevnikov and Stacey L. Wagner and Paul S. Aisen and Mehrdad Shamloo and William C Mobley},
  journal={Science translational medicine},
  year={2009},
  volume={1 7},
  pages={
          7ra17
        }
}
Down syndrome (trisomy 21) is the most common cause of mental retardation in children and leads to marked deficits in contextual learning and memory. In rodents, these tasks require the hippocampus and are mediated by several inputs, particularly those originating in the locus coeruleus. These afferents mainly use norepinephrine as a transmitter. To explore the basis for contextual learning defects in Down syndrome, we examined the Ts65Dn mouse model. These mice, which have three copies of a… CONTINUE READING
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