Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.

@article{Liu2008RestorationOL,
  title={Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery.},
  author={Ji Liu and Wennan Lu and David Reigada and Jonathan Nguyen and Alan Malev Laties and Claire H. Mitchell},
  journal={Investigative ophthalmology & visual science},
  year={2008},
  volume={49 2},
  pages={
          772-80
        }
}
PURPOSE Degradation of engulfed material is primarily mediated by lysosomal enzymes that function optimally within a narrow range of acidic pH values. RPE cells are responsible for daily degradation of photoreceptor outer segments and are thus particularly susceptible to perturbations in lysosomal pH. The authors hypothesized that elevated lysosomal pH levels could slow enzyme activity and encourage accumulation of partially digested material. Consequently, treatment to lower perturbed… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 50 CITATIONS

Induction of lysosomal dilatation, arrested autophagy, and cell death by chloroquine in cultured ARPE-19 cells.

  • Investigative ophthalmology & visual science
  • 2010
VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Lysosomal alkalinization, lipid oxidation, and reduced phagosome clearance triggered by activation of the P2X7 receptor.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2013
VIEW 8 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Cystic fibrosis transmembrane conductance regulator contributes to reacidification of alkalinized lysosomes in RPE cells.

  • American journal of physiology. Cell physiology
  • 2012
VIEW 10 EXCERPTS
CITES BACKGROUND, METHODS & RESULTS
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2018

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 5 Citations per year over the last 3 years

Similar Papers

Loading similar papers…