Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.

@article{Okamoto2005RestorationOL,
  title={Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action.},
  author={Haruka Okamoto and Silvana Obici and Domenico Accili and Luciano Rossetti},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 5},
  pages={1314-22}
}
Partial restoration of insulin receptor Insr expression in brain, liver, and pancreatic beta cells is sufficient for rescuing Insr knockout mice from neonatal death, preventing diabetes ketoacidosis, and normalizing life span and reproductive function. However, the transgenically rescued mice (referred to as L1) have marked hyperinsulinemia, and approximately 30% develop late-onset type 2 diabetes. Analyses of protein expression indicated that L1 mice had modestly reduced Insr content but… CONTINUE READING

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Transgenic rescue of insulin receptor-deficient mice

  • H Okamoto
  • J. Clin. Invest
  • 2004
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