Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1

@article{Michael2001RestorationOI,
  title={Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1},
  author={L. Michael and Z. Wu and R. Cheatham and P. Puigserver and G. Adelmant and J. J. Lehman and D. Kelly and B. Spiegelman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98},
  pages={3820 - 3825}
}
  • L. Michael, Z. Wu, +5 authors B. Spiegelman
  • Published 2001
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Muscle tissue is the major site for insulin-stimulated glucose uptake in vivo, due primarily to the recruitment of the insulin-sensitive glucose transporter (GLUT4) to the plasma membrane. Surprisingly, virtually all cultured muscle cells express little or no GLUT4. We show here that adenovirus-mediated expression of the transcriptional coactivator PGC-1, which is expressed in muscle in vivo but is also deficient in cultured muscle cells, causes the total restoration of GLUT4 mRNA levels to… Expand
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