Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.


Site-directed mutagenesis experiments have suggested a model for the inactivation mechanism of Shaker potassium channels from Drosophila melanogaster. In this model, the first 20 amino acids form a cytoplasmic domain that interacts with the open channel to cause inactivation. The model was tested by the internal application of a synthetic peptide, with the… (More)

2 Figures and Tables


  • Presentations referencing similar topics