Restoration of impaired immune functions of aged animals by chronic bestatin treatment.

@article{BruleyRosset1979RestorationOI,
  title={Restoration of impaired immune functions of aged animals by chronic bestatin treatment.},
  author={Martine Bruley-Rosset and I. Florentin and Nicole Kiger and John Schulz and Georges Math{\'e}},
  journal={Immunology},
  year={1979},
  volume={38 1},
  pages={75-83}
}
An attempt to correct the state of immunodeficiency in old age was made by repeatedly injecting a chemically defined immunostimulating agent, bestatin, to 16 month old (C57Bl/6 x BALB/c) F1 mice. Aged mice were found to have depressed T-cell and B-cell responses but increased ADCC activity. Weekly injections of bestatin over a period of 6 months resulted in varying effects depending on the dose administered. Small doses (10 microgram per injection) were more effective in restoring humoral… CONTINUE READING

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