Restoration of gap junctional intercellular communication by caffeic acid phenethyl ester (CAPE) in a ras-transformed rat liver epithelial cell line.

@article{Na2000RestorationOG,
  title={Restoration of gap junctional intercellular communication by caffeic acid phenethyl ester (CAPE) in a ras-transformed rat liver epithelial cell line.},
  author={Han Kwang Na and Melinda R. Wilson and Kyung Sun Kang and Chia Chien Chang and Dorit Grunberger and James Edward Trosko},
  journal={Cancer letters},
  year={2000},
  volume={157 1},
  pages={31-8}
}
Caffeic acid phenethyl ester (CAPE), an active ingredient of honeybee propolis, has been identified as having anti-inflammatory, anti-viral and anti-cancer properties. Since the deficiency of gap junctional intercellular communication (GJIC) has been shown to be a characteristic of most cancer cells, this study was designed to test the hypothesis that the anti-carcinogenic activity of CAPE might be related to its ability to restore GJIC in tumorigenic GJIC-deficient cells (WB-ras2 cells). The… CONTINUE READING

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