Restoration of frontal activation during a treatment with quetiapine: an fMRI study of blunted affect in schizophrenia

@article{Stip2005RestorationOF,
  title={Restoration of frontal activation during a treatment with quetiapine: an fMRI study of blunted affect in schizophrenia},
  author={E. Stip and C. Fahim and Adham Mancini-Marı̈e and L. A. Bentaleb and M. Beauregard},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2005},
  volume={29},
  pages={21-26}
}
This study investigated changes in cerebral activation related to emotion processing in schizophrenia patients with blunted or flat affect (FA+) during treatment with quetiapine. Using functional magnetic resonance imaging (fMRI), brain activation in 12 FA+ schizophrenia patients during passive viewing of sad film excerpts was studied before and after a median of 5.5-months treatment with quetiapine. Random-effects 'paired sample t-test' analyses of brain activation before quetiapine (contrast… Expand
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