Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.

  title={Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.},
  author={David G Harrison and Mickey L. Armstrong and P C Freiman and Donald D. Heistad},
  journal={The Journal of clinical investigation},
  volume={80 6},
Atherosclerosis results in impaired relaxation to acetylcholine, thrombin, and the calcium ionophore A23187, all agents that require the presence of endothelium. We now report that dietary treatment of atherosclerosis in monkeys not only produces morphological improvement of the atherosclerotic lesion but restores endothelium-dependent vascular relaxation to normal. Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is… CONTINUE READING


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