Restoration of corpus luteum angiogenesis in immature hypothyroid rdw rats after thyroxine treatment: morphologic and molecular evidence.

@article{Macchiarelli2013RestorationOC,
  title={Restoration of corpus luteum angiogenesis in immature hypothyroid rdw rats after thyroxine treatment: morphologic and molecular evidence.},
  author={Guido Macchiarelli and Maria Grazia Palmerini and Stefania Nottola and Sandra Cecconi and Kentaro Tanemura and Eimei Sato},
  journal={Theriogenology},
  year={2013},
  volume={79 1},
  pages={
          116-26
        }
}
Thyroxine (T4) plus gonadotropins might stimulate ovarian follicular angiogenesis in immature infertile hypothyroid rdw rats by upregulating mRNA expression of major angiogenic factors. Development of growing corpus luteum (CL) is strongly related to angiogenesis and to morphofunctional development of microcirculation. Our aim was to investigate if T4 is involved in CL angiogenesis and in the activation of capillary cells and angiogenic factors after ovulation in a spontaneous model of… CONTINUE READING
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