Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light.

@article{Abraham2006RestorationOC,
  title={Restoration of circadian rhythmicity in circadian clock-deficient mice in constant light.},
  author={Diya Abraham and Robert Dallmann and Stephan Steinlechner and Urs Albrecht and Gregor Eichele and Henrik Oster},
  journal={Journal of biological rhythms},
  year={2006},
  volume={21 3},
  pages={169-76}
}
In mammals, circadian rhythms in behavior and physiology are controlled by a central pacemaker, the SCN, and subordinated clocks throughout the body. On the molecular level, these clocks are based on transcriptional/translational feedback loops involving a set of clock genes that regulate their own transcription. Among the components driving the mammalian circadian clock are the Period 1 and 2 (Per1 and Per2) and Cryptochrome 1 and 2 (Cry1 and Cry2) genes. In the present study, the authors… CONTINUE READING