Restoration of circadian behavioural rhythms by gene transfer in Drosophila

@article{Bargiello1984RestorationOC,
  title={Restoration of circadian behavioural rhythms by gene transfer in Drosophila},
  author={Thaddeus A. Bargiello and F Rob Jackson and Michael W. Young},
  journal={Nature},
  year={1984},
  volume={312},
  pages={752-754}
}
The per locus of Drosophila melanogaster has a fundamental role in the construction or maintenance of a biological clock. Three classes of per mutations have been identified: perl mutants have circadian behavioural rhythms with a 29-h rather than a 24-h period, pers mutants have short-period rhythms of 19 h, and per0 mutants have no detectable circadian rhythms1–4. Each of these mutations has a corresponding influence on the 55-s periodicity of male courtship song5. Long-and short-period… 
Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock
TLDR
It is suggested that perl and pers mutants produce hypoactive and hyperactive per proteins, respectively, which are inversely correlated with period length, so that flies with lowest levels of the per product have slow-running biological clocks.
Product of per locus of Drosophila shares homology with proteoglycans
TLDR
A fragment of DNA of ∼7 kilobases (kb) encoding a 4.5-kb poly(A)+ RNA restores rhyth-micity when transduced into Drosophila carrying mutations5,6 or chromosomal deletions5 of the per locus and the sequence of this biologically active segment of DNA is reported.
Genetic screens for clock mutants in Drosophila.
  • J. Price
  • Biology
    Methods in enzymology
  • 2005
An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates
TLDR
The results of a search for sequences homologous to the per locus DNA in the genomic DNA of several species of vertebrates show an unusual, tandemly repeated sequence forming a portion of the 4.5-kb per transcript is homologously to DNA in chicken, mouse and man.
New short period mutations of the Drosophila clock gene per
A new mutation at the period locus of Drosophila melanogaster with some novel effects on circadian rhythms.
A new period mutation has been induced and characterized in D. melanogaster. It causes flies to be apparently arrhythmic in tests of locomotor activity and thus is superficially similar to the
Circadian rhythms of female mating activity governed by clock genes in Drosophila
  • T. Sakai, N. Ishida
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
TLDR
It is demonstrated that wild-type Drosophila melanogaster display a robust circadian rhythm in the mating activity, and that these rhythms are abolished in period- or timeless-null mutant flies (per01 and tim01).
Circadian Rhythms and Sleep in Drosophila melanogaster
TLDR
Flies remain a valuable tool for both discovery of novel molecules and deep mechanistic understanding of sleep and circadian rhythms, and are beginning to understand how the identified molecules and neurons interact with each other, and with the environment, to regulate sleep.
The clock gene period in the housefly, Musca domestica : a molecular analysis
TLDR
A comparative study suggests that the current model based on the negative feedback loop may be inadequate to explain the molecular mechanism underlying the circadian clock.
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