Restoration of circadian behavioural rhythms by gene transfer in Drosophila
@article{Bargiello1984RestorationOC,
title={Restoration of circadian behavioural rhythms by gene transfer in Drosophila},
author={Thaddeus A. Bargiello and F Rob Jackson and Michael W. Young},
journal={Nature},
year={1984},
volume={312},
pages={752-754}
}The per locus of Drosophila melanogaster has a fundamental role in the construction or maintenance of a biological clock. Three classes of per mutations have been identified: perl mutants have circadian behavioural rhythms with a 29-h rather than a 24-h period, pers mutants have short-period rhythms of 19 h, and per0 mutants have no detectable circadian rhythms1–4. Each of these mutations has a corresponding influence on the 55-s periodicity of male courtship song5. Long-and short-period…
417 Citations
Changes in abundance or structure of the per gene product can alter periodicity of the Drosophila clock
- BiologyNature
- 1987
It is suggested that perl and pers mutants produce hypoactive and hyperactive per proteins, respectively, which are inversely correlated with period length, so that flies with lowest levels of the per product have slow-running biological clocks.
Product of per locus of Drosophila shares homology with proteoglycans
- BiologyNature
- 1986
A fragment of DNA of ∼7 kilobases (kb) encoding a 4.5-kb poly(A)+ RNA restores rhyth-micity when transduced into Drosophila carrying mutations5,6 or chromosomal deletions5 of the per locus and the sequence of this biologically active segment of DNA is reported.
Circadian rhythms in Drosophila melanogaster: analysis of period as a function of gene dosage at the per (period) locus.
- BiologyJournal of theoretical biology
- 1986
An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates
- BiologyNature
- 1985
The results of a search for sequences homologous to the per locus DNA in the genomic DNA of several species of vertebrates show an unusual, tandemly repeated sequence forming a portion of the 4.5-kb per transcript is homologously to DNA in chicken, mouse and man.
A new mutation at the period locus of Drosophila melanogaster with some novel effects on circadian rhythms.
- BiologyJournal of neurogenetics
- 1989
A new period mutation has been induced and characterized in D. melanogaster. It causes flies to be apparently arrhythmic in tests of locomotor activity and thus is superficially similar to the…
Circadian rhythms of female mating activity governed by clock genes in Drosophila
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2001
It is demonstrated that wild-type Drosophila melanogaster display a robust circadian rhythm in the mating activity, and that these rhythms are abolished in period- or timeless-null mutant flies (per01 and tim01).
Circadian Rhythms and Sleep in Drosophila melanogaster
- BiologyGenetics
- 2017
Flies remain a valuable tool for both discovery of novel molecules and deep mechanistic understanding of sleep and circadian rhythms, and are beginning to understand how the identified molecules and neurons interact with each other, and with the environment, to regulate sleep.
The clock gene period in the housefly, Musca domestica : a molecular analysis
- Biology
- 1998
A comparative study suggests that the current model based on the negative feedback loop may be inadequate to explain the molecular mechanism underlying the circadian clock.
References
SHOWING 1-10 OF 11 REFERENCES
Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1980
Both circadian rhythms and a very short, noncircadian oscillation appear to be influenced by the same gene.
Molecular analysis of the period locus in Drosophila melanogaster and identification of a transcript involved in biological rhythms
- BiologyCell
- 1984
The Isolation of Biological Rhythm Mutations on the Autosomes of Drosophila melanogaster
- Biology
- 1983
Like an early-emerging strain previously isolated in Drosophila pseudoobscura thepsi strains, psi-2 brings about an abnormal synchronization of locomotor activity to light-dark cycles and lengthens periods for the activity rhythm in adult emergence.
Molecular genetics of a biological clock in Drosophila.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1984
Physical characterization of a series of chromosomal rearrangements altering per locus activity indicates that DNA affecting behavioral rhythms is found in a 7.1-kb HindIII fragment.
Clock mutants of Drosophila melanogaster.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1971
Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed and all these mutations appear to involve the same functional gene on the X chromosome.
The effect of chromosomal position on the expression of the drosophila xanthine dehydrogenase gene
- BiologyCell
- 1983
Correct developmental expression of a cloned alcohol dehydrogenase gene transduced into the drosophila germ line
- BiologyCell
- 1983
Vectors for P element-mediated gene transfer in Drosophila.
- BiologyNucleic acids research
- 1983
This work has constructed and tested several new vectors for P element-mediated gene transfer and describes a genomic sequence arrangement that apparently arose by the transposition of a 54 kb composite P element from a tetramer plasmid.
Nonessential Sequences, Genes, and the Polytene Chromosome Bands of DROSOPHILA MELANOGASTER.
- BiologyGenetics
- 1978
The discovery of these units, which are not allelic to any of the loci previously known, makes it clear that division 3B contains more genes than polytene chromosome bands, while portions of 3A and 3C seem to have no functional significance.
Circadian rhythms and the circadian organization of living systems.
- PsychologyCold Spring Harbor symposia on quantitative biology
- 1960
The writing of this paper has been influenced by strongly held convictions and concerns the need at this juncture in the study of “daily” rhythms for bold and explicit theory formation.