Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells.

@article{Mouquet2005RestorationOC,
  title={Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells.},
  author={Fr{\'e}d{\'e}ric Mouquet and Otmar Pfister and Mohit Jain and Angelos Oikonomopoulos and Soeun Ngoy and Ross S. Summer and Alan Fine and Ronglih Liao},
  journal={Circulation research},
  year={2005},
  volume={97 11},
  pages={1090-2}
}
Tissue-specific progenitor cells contribute to local cellular regeneration and maintain organ function. Recently, we have determined that cardiac side-population (CSP) cells represent a distinct cardiac progenitor cell population, capable of in vitro differentiation into functional cardiomyocytes. The response of endogenous CSP to myocardial injury, however, and the cellular mechanisms that maintain this cardiac progenitor cell pool in vivo remain unknown. In this report we demonstrate that… CONTINUE READING