Restoration of adipose function in obese glucose-tolerant men following pioglitazone treatment is associated with CCAAT enhancer-binding protein β up-regulation.

@article{Powell2012RestorationOA,
  title={Restoration of adipose function in obese glucose-tolerant men following pioglitazone treatment is associated with CCAAT enhancer-binding protein β up-regulation.},
  author={Lesley A Powell and Paul Crowe and Chenchi Kankara and Jennifer McPeake and David R. McCance and Ian S Young and Elisabeth R. Trimble and Ann McGinty},
  journal={Clinical science},
  year={2012},
  volume={123 3},
  pages={135-46}
}
Obese AT (adipose tissue) exhibits increased macrophage number. Pro-inflammatory CD16+ peripheral monocyte numbers are also reported to increase with obesity. The present study was undertaken to simultaneously investigate obesity-associated changes in CD16+ monocytes and ATMs (AT macrophages). In addition, a pilot randomized placebo controlled trial using the PPAR (peroxisome-proliferator-activated receptor) agonists, pioglitazone and fenofibrate was performed to determine their effects on CD14… CONTINUE READING