Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer.

@article{Tu2009RestorationOX,
  title={Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer.},
  author={Shui Tu and Peter Liston and Jian Cui and Marie Chia Mi Lin and X. H. Jiang and Yi Yang and Qing Gu and Shi Hu Jiang and Ching Tung Lum and Hsiang Fu Kung and R. G. Korneluk and Benjamin Chun-yu Wong},
  journal={International journal of cancer},
  year={2009},
  volume={125 3},
  pages={688-97}
}
XAF1 (XIAP-associated factor 1) is a novel XIAP binding protein that can antagonize XIAP and sensitize cells to other cell death triggers. Our previous results have shown that aberrant hypermethylation of the CpG sites in XAF1 promoter is strongly associated with lower expression of XAF1 in gastric cancers. In our study, we investigated the effect of restoration of XAF1 expression on growth of gastric cancers. We found that the restoration of XAF1 expression suppressed anchorage-dependent and… CONTINUE READING