Restoration of Physiologically Responsive Low-Density Lipoprotein Receptor-Mediated Endocytosis in Genetically Deficient Induced Pluripotent Stem Cells

@inproceedings{Ramakrishnan2015RestorationOP,
  title={Restoration of Physiologically Responsive Low-Density Lipoprotein Receptor-Mediated Endocytosis in Genetically Deficient Induced Pluripotent Stem Cells},
  author={Venkat M. Ramakrishnan and Jeong-Yeh Yang and Kevin T. Tien and Thomas R. McKinley and Braden R. Bocard and John G. Maijub and Patrick O. Burchell and Stuart K. Williams and Marvin E. Morris and James B. Hoying and Richard Wade-Martins and Franklin D. West and Nolan L. Boyd},
  booktitle={Scientific reports},
  year={2015}
}
Acquiring sufficient amounts of high-quality cells remains an impediment to cell-based therapies. Induced pluripotent stem cells (iPSC) may be an unparalleled source, but autologous iPSC likely retain deficiencies requiring correction. We present a strategy for restoring physiological function in genetically deficient iPSC utilizing the low-density lipoprotein receptor (LDLR) deficiency Familial Hypercholesterolemia (FH) as our model. FH fibroblasts were reprogrammed into iPSC using synthetic… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 52 references

OPTN/SRTR 2012 Annual Data Report: liver.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2014

liver

Kim, W. R. et al. OPTNSRTR 2012 Annual Data Report
Am J Transplant. 14, 69–96, doi: 10.1111/ajt.12581 • 2014

Generation of a functional liver tissue mimic using adipose stromal vascular fraction cell-derived vasculatures

Nunes, S S.
Sci Rep • 2013

Hepatocyte polarity.

Comprehensive Physiology • 2013

guidance for clinicians to prevent coronary heart disease: consensus statement of the European Atherosclerosis Society

Nordestgaard, B. G. et al. Familial hypercholesterolaemia is underdiagnosed, undertreated in the general population
Eur Heart J. 34, 3478–3490a, doi: 10.1093/eurheartj/eht273 • 2013

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