Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors.

@article{Wu2008RestorationOP,
  title={Restoration of PTEN expression alters the sensitivity of prostate cancer cells to EGFR inhibitors.},
  author={Zhong Wu and Daniel G. Gioeli and Mark C Conaway and Michael D Weber and Dan Theodorescu},
  journal={The Prostate},
  year={2008},
  volume={68 9},
  pages={935-44}
}
INTRODUCTION Prostate cancer (CaP) progression from an androgen-dependent to an androgen-independent state is associated with overexpression of EGFR family members or activation of their downstream signaling pathways, such as PI3K-Akt and MAPK. Although there are data implicating PI3K-Akt or MAPK pathway activation with resistance to EGFR inhibitors in CaP, the potential cross-talk between these pathways in response to EGFR or MAPK inhibitors remains to be examined. METHODS Cross-talk between… CONTINUE READING
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