Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with α-Lipoic Acid

@inproceedings{Koga2012RestorationOD,
  title={Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with α-Lipoic Acid},
  author={Takayuki Koga and Takumi Ishida and Tomoki Takeda and Yuji Ishii and Hiroshi Uchi and Kiyomi Tsukimori and Midori Yamamoto and Masaru Himeno and Masutaka Furue and Hideyuki Yamada},
  booktitle={PloS one},
  year={2012}
}
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disruptor, causes reproductive and developmental toxic effects in pups following maternal exposure in a number of animal models. Our previous studies have demonstrated that TCDD imprints sexual immaturity by suppressing the expression of fetal pituitary gonadotropins, the regulators of gonadal steroidogenesis. In the present study, we discovered that all TCDD-produced damage to fetal production of pituitary gonadotropins as well as… CONTINUE READING