Restless legs syndrome

  title={Restless legs syndrome},
  author={Suzanne Lesage and Christopher J. Earley},
  journal={Current Treatment Options in Neurology},
  • S. Lesage, C. Earley
  • Published 22 May 2003
  • Medicine, Psychology
  • Current Treatment Options in Neurology
Opinion statementIn the past 10 years, restless legs syndrome (RLS) has gained recognition as a common sleep disorder. There are several therapeutic options in treating patients with RLS. RLS causes significant sleep disturbance and negatively impacts on patient quality of life. Pharmacologic treatment can result in improved sleep and quality of life issues. RLS patients should be evaluated for iron deficiency anemia; iron replacement in deficient patients may lead to a resolution of symptoms… 

Investigational approaches to therapies for restless legs syndrome

Oxycodone-naloxone has demonstrated a significant and sustained effect on patients with severe RLS inadequately controlled with first-line drugs; it could be used as a long-term treatment option in severe cases of RLS for which alternative satisfactory drug regimens are unavailable.

Strategies for the Treatment of Restless Legs Syndrome

The α2δ anticonvulsants may now also be considered as drugs of choice for moderate to severe RLS patients, especially for those who have failed other therapies since they are very effective for severe cases.

Current treatment options for restless legs syndrome

Treatment of RLS is generally symptomatic, a causal therapy is possible only in the secondary forms and opioids and anticonvulsants such as gabapentin or benzodiazepines, are regarded as second-line treatment, although dopaminergic drugs may also be helpful.

Restless legs syndrome: a clinical update.

Restless legs syndrome (RLS) is a common and often disabling sensorimotor disorder. Epidemiologic studies suggest that RLS is an underrecognized and undertreated disorder affecting both children and

Bupropion XL use in comorbidity of depression and restless leg syndrome: a case report -

It is concluded that bupropion, as a selective noradrenergic-dopaminergic reuptake inhibitor can be a good alternative to the SSRIs for patients, who suffer from both depression and RLS.

Restless Legs Syndrome: Contemporary Diagnosis and Treatment.

RLS significantly impacts patients' quality of life and remains a therapeutic area sorely in need of innovation and a further pipeline of new, biologically informed therapies.

New paradigms in the treatment of restless legs syndrome

Clinicians must be aware of the high prevalence of RLS, the potential for onset before age 20, and the various clinical presentations, and rely on dopamine agonists first-line therapy and provide symptom relief in 70% to 100% of patients.

Treatment of pediatric restless legs syndrome.

Levetiracetam can be effective in the treatment of restless legs syndrome with periodic limb movements in sleep: report of two cases

Two patients affected by RLS with PLMS who became unresponsive to the traditional dopaminergic agents and developed augmentation were treated with the antiepileptic drug levetiracetam and showed a clear and persistent clinical improvement of both RLS symptoms and PLMS.

Sequential Compression Devices for Treatment of Restless Legs Syndrome

In this group of patients, wearing the SCD in the evening for an hour improved symptoms of RLS and improved quality of life, with complete resolution of symptoms in 3 of 10 patients.



Restless legs syndrome: Treatment with dopaminergic agents

The direct dopamine receptor agonists have largely replaced levodopa as the most effective treatment for RLS, and pergolide, pramipexole, ropinirole, and cabergoline have all been shown to alleviate RLS symptoms in 70 to 100% of patients.

Role of Dopamine Receptor Agonists in the Treatment of Restless Legs Syndrome

It was shown that, for example, pergolide, ropinirole, pramipexole and cabergoline alleviated RLS symptoms in 70–90% of patients and a new non-oral (transdermal) formulation of one dopamine receptor agonist, rotigotine, has recently been developed and shown to be efficacious in RLS.

An algorithm for the management of restless legs syndrome.

The role of carbidopa/levodopa, dopamine agonists, opioids, benzodiazepines, and anticonvulsants for the different types of the disorder is delineated.

Ropinirole for restless legs syndrome

  • W. Ondo
  • Medicine
    Movement disorders : official journal of the Movement Disorder Society
  • 1999
Encouraging preliminary results justify larger and more controlled trials of ropinirole in patients with RLS and further investigate the mechanisms behind the desire to move the extremities.

Restless legs syndrome. A review.

Treatment of the underlying cause of restless legs syndrome, when possible, usually relieves the symptoms and levodopa, bromocriptine mesylate, opioids, carbamazepine, clonazepam, and clonidine hydrochloride have proved to be effective.

Restless legs syndrome

Restless legs syndrome is a common cause of insomnia related to problems with sleep initiation and sleep maintenance, unrefreshing sleep, and excessive daytime sleepiness, and it may signify an underlying medical condition.

Restless Legs Syndrome Treatment with Dopaminergic Drugs

These dopaminergic drugs decreased the times of waking up and staying awake periods at a statistically significant level (p changed between 0.025 and 0.01, t test) compared with placebo.

Restless Legs Syndrome: A Clinical Study of 55 Patients

RLS is a clinically pleomorphic syndrome, reflecting the contribution of multiple genetic and acquired factors in the pathogenesis of RLS.

Epidemiology of restless legs symptoms in adults.

The prevalence of restless legs in the general adult population is high and may be associated with decreased well-being, emphasizing the need for further research and greater medical recognition of this condition.

Restless legs syndrome and periodic limb movement disorder.

  • K. ParkerD. Rye
  • Medicine, Psychology
    The Nursing clinics of North America
  • 2002