Restless legs syndrome

@article{Clemens2006RestlessLS,
  title={Restless legs syndrome},
  author={Stefan Clemens and David B. Rye and Shawn Hochman},
  journal={Neurology},
  year={2006},
  volume={67},
  pages={125 - 130}
}
Restless legs syndrome (RLS) involves abnormal limb sensations that diminish with motor activity, worsen at rest, have a circadian peak in expression in the evening and at night, and can severely disrupt sleep. Primary treatment is directed at CNS dopaminergic systems, particularly activation of D2-like (D2, D3, and D4) receptors. Although RLS affects 2% to 15% of the general population, the neural circuitry contributing to RLS remains speculative, and there is currently no accepted animal… 
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Cannabis for Restless Legs Syndrome.
  • I. Ghorayeb
  • Medicine, Biology
    Advances in experimental medicine and biology
  • 2021
TLDR
The antinociceptive effect of marijuana has been documented in many painful neurological conditions and the potential benefit of cannabis use in patients with refractory RLS should be questioned by robust clinical trials.
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