Restless legs syndrome: update on pathogenesis

@article{Dauvilliers2013RestlessLS,
  title={Restless legs syndrome: update on pathogenesis},
  author={Yves Dauvilliers and Juliane Winkelmann},
  journal={Current Opinion in Pulmonary Medicine},
  year={2013},
  volume={19},
  pages={594–600}
}
Purpose of review Much recent progress has been made in understanding restless legs syndrome (RLS), focusing mainly on genetic predisposition and dysregulation of iron metabolism and the dopaminergic system. We provide in this review an update of the most recent scientific advances on the pathophysiology of primary RLS. Recent findings Genome-wide association studies identified six genetic variants including MEIS1 and BTBD9 with potential relationships with iron. Brain iron level is low in RLS… 
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