Restless Legs Syndrome: A Review of Clinical and Pathophysiologic Features

@article{Allen2001RestlessLS,
  title={Restless Legs Syndrome: A Review of Clinical and Pathophysiologic Features},
  author={Richard P. Allen and Christopher J. Earley},
  journal={Journal of Clinical Neurophysiology},
  year={2001},
  volume={18},
  pages={128-147}
}
  • R. Allen, C. Earley
  • Published 1 March 2001
  • Medicine, Biology
  • Journal of Clinical Neurophysiology
Summary Restlesslegs syndrome (RLS), although long ignored and still much underdiagnosed,disrupts the life and sleep considerably of those who have it. Recent clinicaland basic research provides for better definition and pathophysiologicunderstanding of the disorder. The body of knowledge about this disorder hasbeen expanding rapidly during the past decade and it has altered our conceptsof this disorder. This review of RLS covers history, diagnosis, morbidity ofsleep disturbance, relation to… 
Restless legs syndrome: pathophysiology and clinical aspects
TLDR
Treatment with opiates and gabapentin is proposed for cases not responding to dopamine agonists and/or when pain is the presenting symptom, and iron therapy is recommended only in patients with low level of ferritin.
Treating restless legs syndrome: current pathophysiological concepts and clinical trials.
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  • Medicine
    Expert opinion on investigational drugs
  • 2002
TLDR
The present review attempts to explain current strategies of treatment for restless legs syndrome in relation to aetiological, genetic and pathophysiological findings.
Restless legs syndrome and periodic limb movement disorder.
  • K. ParkerD. Rye
  • Medicine, Psychology
    The Nursing clinics of North America
  • 2002
Restless Legs Syndrome: A Review
TLDR
The clinical characteristics, epidemiology, diagnosis, pathogenesis, and treatment of Restless legs syndrome are reviewed.
Restless legs syndrome: diagnosis and review of management options
TLDR
This review addresses the diagnostic issues, the differential diagnosis, and the evidence base for treatment of the common condition Restless legs syndrome.
[Restless legs syndrome].
TLDR
Dopaminergic stimulation with levodopa or dopamine agonists is the first choice in idiopathic restless legs syndrome, but the long-term adverse effect of augmentation should be carefully monitored.
Restless legs syndrome in patients on dialysis.
TLDR
Treatment in uremic RLS should involve the reduction of potential exacerbating agents, correction of anemia (with erythropoietin and iron), and use of levodopa or dopamine agonists.
Restless legs syndrome: A sensorimotor disorder of sleep/ wake motor regulation
  • W. Hening
  • Psychology, Medicine
    Current neurology and neuroscience reports
  • 2002
TLDR
Therapeutically, studies have shown the dopamine agonists to be the most reliable treatment for severe cases, whereas other recent studies have successfully utilized a number of other medications, including levodopa, opioids, and anticonvulsants.
Emerging drugs for restless legs syndrome
TLDR
Evidence-based and clinical guidelines identify dopamine agonists as a first-line treatment for daily restless legs symptoms and several promising new therapies with nondopamine profiles are under development for RLS.
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TLDR
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