Resting state of the human proton channel dimer in a lipid bilayer.

Abstract

The voltage-gated proton channel Hv1 plays a critical role in the fast proton translocation that underlies a wide range of physiological functions, including the phagocytic respiratory burst, sperm motility, apoptosis, and metastatic cancer. Both voltage activation and proton conduction are carried out by a voltage-sensing domain (VSD) with strong… (More)
DOI: 10.1073/pnas.1515043112

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