Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease.

  title={Resting bold fMRI differentiates dementia with Lewy bodies vs Alzheimer disease.},
  author={James E. Galvin and Joseph L. Price and Zhifang Yan and John C. Morris and Yvette I. Sheline},
  volume={76 21},
OBJECTIVE Clinicopathologic phenotypes of dementia with Lewy bodies (DLB) and Alzheimer disease (AD) often overlap, making discrimination difficult. We performed resting state blood oxygen level-dependent (BOLD) functional connectivity MRI (fcMRI) to determine whether there were differences between AD and DLB. METHODS Participants (n = 88) enrolled in a longitudinal study of memory and aging underwent 3-T fcMRI. Clinical diagnoses of probable DLB (n = 15) were made according to published… CONTINUE READING


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