Responsiveness to methamphetamine in adulthood is altered by prenatal exposure in rats.

  title={Responsiveness to methamphetamine in adulthood is altered by prenatal exposure in rats.},
  author={Barbora Schutov{\'a} and Lenka Hrub{\'a} and Marie Pometlov{\'a} and Richard Rokyta and Romana {\vS}lamberov{\'a}},
  journal={Physiology & behavior},
  volume={99 3},
Methamphetamine (MA) is a drug causing potent psychomotor activation. The aim of the present study was: (1) to assess the effect of prenatal and acute MA administration on behavior in adult male rats and (2) to find out if the prenatal exposure to MA increases sensitivity to acute MA application in adulthood. Behavior of adult male rats prenatally exposed to MA (5mg/kg) or saline was tested in Open field (OF) and Elevated plus maze (EPM). Subcutaneously administered MA (1mg/kg) or saline were… CONTINUE READING
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