Responsiveness of selenoproteins to dietary selenium.

@article{Allan1999ResponsivenessOS,
  title={Responsiveness of selenoproteins to dietary selenium.},
  author={C. Allan and G. Lacourciere and T. Stadtman},
  journal={Annual review of nutrition},
  year={1999},
  volume={19},
  pages={
          1-16
        }
}
Selenocysteine-containing enzymes that have been identified in mammals include the glutathione peroxidase family (GPX1, GPX2, GPX3, and GPX4), one or more iodothyronine deiodinases and two thioredixin reductases. Selenoprotein P, a glycoprotein that contains 10 selenocysteine residues per 43 kDa polypeptide and selenoprotein W, a 10 kDa muscle protein, are unidentified as to function. Levels of all of these selenocysteine-containing proteins in various tissues are affected to different extents… Expand
Characterization of selenoprotein P as a selenium supply protein.
TLDR
This finding suggests that serum contains some usable form of Se, and suggests that selenoprotein P functions as a Se-supply protein, delivering Se to the cells. Expand
Selenoprotein P: properties, functions, and regulation.
  • V. Mostert
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • 2000
TLDR
Analysis of the human SeP promoter indicates a transcriptional regulation of SeP by inflammatory mediators and a function as an extracellular antioxidant seems most probable. Expand
Mechanism and regulation of selenoprotein synthesis.
TLDR
This review describes emerging themes from studies on the mechanism, kinetics, and efficiency of Sec insertion in prokaryotes, and recent developments that provide mechanistic insight into how the eukaryotic ribosome distinguishes between UGA/Sec and U GA/stop codons are discussed. Expand
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Knockout of Selenoprotein V Affects Regulation of Selenoprotein Expression by Dietary Selenium and Fat Intakes in Mice.
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If the daily recommended intake of Se has to be increased and that the age of ewes also should be taken into account, when planning diets and daily allowances of mineral feed are discussed. Expand
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TLDR
The results suggest that the systemic response to selenium deficiency and selenomethionine excess involves the down- regulation of some selenoproteins such as Gpx1/Gpx3 and up-regulation ofselenium-containing proteins (not seleniproteins), respectively. Expand
Selenium Deficiency Influences Nitric Oxide and Selenoproteins in Pancreas of Chickens
TLDR
It is suggested that Se deficiency induced pancreatic injury by influencing NO and selenoproteins in pancreas of chickens and the correlation analysis suggested that NO had a strong negative correlation with GPX1, glutathione peroxidase 2 (GPX2), GPX3, DIO1,selenoprotein K (SELK), SELI, SEPX1 and SPS2. Expand
Selenium, selenoproteins and the thyroid gland: interactions in health and disease
  • L. Schomburg
  • Biology, Medicine
  • Nature Reviews Endocrinology
  • 2012
TLDR
The baseline selenium status of an individual could constitute the most important parameter modifying the outcome of selenum supplementation, which might primarily disrupt self-amplifying cycles of the endocrine–immune system interface rectifying the interaction of lymphocytes with thyroid autoantigens. Expand
Selenocysteine incorporation machinery and the role of selenoproteins in development and health.
TLDR
This chapter discusses the means by which amino acid selenocysteine (Sec) is biosynthesized and incorporated into protein; the generation of mouse models for elucidating the role of selenoproteins in development and health; the identity and functions of Selenoprotein; and the distribution and evolution of the amino acid Sec insertion machinery among eukaryotes. Expand
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