Responsiveness of isolated monkey coronary arteries contracted with alpha 1- and alpha 2-adrenoceptor agonists to diltiazem.

  • Nobuo Toda
  • Published 1988 in European journal of pharmacology


Diltiazem induced a concentration-dependent relaxation of monkey coronary arterial strips which were partially contracted with clonidine, phenylephrine, norepinephrine, prostaglandin F2 alpha. This relaxation occurred to a similar extent, but was significantly less than that observed in arteries contracted with K+. Contractions mediated via alpha 2… (More)