Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes.

@article{Rosen1994ResponsivenessOC,
  title={Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes.},
  author={V Benezra Rosen and John Nove and Jeffrey Song and R Scott Thies and Karen Cox and John M. Wozney},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1994},
  volume={9 11},
  pages={1759-68}
}
There is growing evidence to suggest that BMPs are among the signals necessary to create the embryonic skeleton, but how these regulatory molecules enter the pathways of embryonic bone formation remains to be defined. The earliest steps of endochondral bone formation, consisting of mesenchymal condensation and chondrogenesis, have been shown to result directly from BMP-2 action. To determine whether the transition from chondrogenesis to osteogenesis occurring later in endochondral bone… CONTINUE READING
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