Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo.

@article{Hachisuka2010ResponsivenessOC,
  title={Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo.},
  author={Junichi Hachisuka and Hidemasa Furue and Masutaka Furue and Masahiro Yoshimura},
  journal={Journal of neurophysiology},
  year={2010},
  volume={104 1},
  pages={
          271-9
        }
}
Itching is a common symptom in dermatologic diseases and causes restless scratching of the skin, which aggravates the condition. The mechanism of the itch sensation, however, is enigmatic. The present study included behavioral tests and electrophysiological recordings from rat dorsal root ganglion (DRG) neurons in vivo to analyze the response to pruritic stimuli induced by topical application of 5-hydroxytryptamine (5-HT) to the skin. Topically applied 5-HT to the rostral back evoked scratching… CONTINUE READING

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