Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes
@article{Aggeli1997ResponsiveGF, title={Responsive gels formed by the spontaneous self-assembly of peptides into polymeric β-sheet tapes}, author={A. Aggeli and M. Bell and N. Boden and J. N. Keen and P. Knowles and T. McLeish and M. Pitkeathly and S. Radford}, journal={Nature}, year={1997}, volume={386}, pages={259-262} }
Molecular self-assembly is becoming an increasingly popular route to new supramolecular structures and molecular materials1–7. The inspiration for such structures is commonly derived from self-assembling systems in biology. Here we show that a biological motif, the peptide β-sheet, can be exploited in designed oligopeptides that self-assemble into polymeric tapes and with potentially useful mechanical properties. We describe the construction of oligopeptides, rationally designed or based on… Expand
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References
SHOWING 1-10 OF 31 REFERENCES
Spontaneous assembly of a self-complementary oligopeptide to form a stable macroscopic membrane.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1993
- 957
- PDF
Chemical sequence control of beta-sheet assembly in macromolecular crystals of periodic polypeptides.
- Chemistry, Medicine
- Science
- 1994
- 208
Use of a gel‐forming dipeptide derivative as a carrier for antigen presentation
- Chemistry, Medicine
- Journal of peptide science : an official publication of the European Peptide Society
- 1995
- 94
A recipe for designing water‐soluble, β‐sheet‐forming peptides
- Chemistry, Medicine
- Protein science : a publication of the Protein Society
- 1996
- 78
Perspectives in Supramolecular Chemistry—From Molecular Recognition towards Molecular Information Processing and Self‐Organization
- Materials Science
- 1990
- 2,251
Far-UV circular dichroism reveals a conformational switch in a peptide fragment from the beta-sheet of hen lysozyme.
- Chemistry, Medicine
- Biochemistry
- 1994
- 44
Context-dependent secondary structure formation of a designed protein sequence
- Biology, Medicine
- Nature
- 1996
- 360
- PDF