Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats.

@article{Wanstall1992ResponsesTV,
  title={Responses to vasodilator drugs on pulmonary artery preparations from pulmonary hypertensive rats.},
  author={Janet C. Wanstall and Stella R. O'Donnell},
  journal={British journal of pharmacology},
  year={1992},
  volume={105 1},
  pages={152-8}
}
1. Relaxant responses to six vasodilator drugs, with different mechanisms of action, were examined on noradrenaline (0.1 microM)-contracted ring preparations of pulmonary artery and aorta taken from rats with pulmonary hypertension induced by monocrotaline or chronic hypoxia. 2. On pulmonary artery preparations from monocrotaline-treated rats, compared with controls, (a) the maximum relaxation to pinacidil and cromakalim was significantly increased, but their potency (negative log EC50) was… CONTINUE READING

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