Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.

@article{Grall2003ResponsesTT,
  title={Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.},
  author={Franck T Grall and Xuesong Gu and Lujian Tan and Je-Yoel Cho and Mehmet Sait Inan and Allison R Pettit and Usanee Thamrongsak and Bob K. Choy and Cathy Manning and Yasmin W Akbarali and Luiz Fernando Celidonio Zerbini and Susan A Rudders and Steven Robert Goldring and Ellen M. Gravallese and P. Oettgen and Mary B Goldring and T. A. Libermann},
  journal={Arthritis and rheumatism},
  year={2003},
  volume={48 5},
  pages={1249-60}
}
OBJECTIVE To investigate the expression of the novel Ets transcription factor ESE-1 in rheumatoid synovium and in cells derived from joint tissues, and to analyze the role of nuclear factor kappaB (NF-kappaB) as one of the central downstream targets in mediating the induction of ESE-1 by proinflammatory cytokines. METHODS ESE-1 protein expression was analyzed by immunohistochemistry using antibodies in synovial tissues from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). ESE… CONTINUE READING

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