Responses to altered oxygen tension are distinct between human stem cells of high and low chondrogenic capacity

@inproceedings{Anderson2016ResponsesTA,
  title={Responses to altered oxygen tension are distinct between human stem cells of high and low chondrogenic capacity},
  author={Devon E. Anderson and Brandon D. Markway and Derek Bond and Helen E. McCarthy and Brian Johnstone},
  booktitle={Stem Cell Research & Therapy},
  year={2016}
}
Lowering oxygen from atmospheric level (hyperoxia) to the physiological level (physioxia) of articular cartilage promotes mesenchymal stem cell (MSC) chondrogenesis. However, the literature is equivocal regarding the benefits of physioxic culture on preventing hypertrophy of MSC-derived chondrocytes. Articular cartilage progenitors (ACPs) undergo chondrogenic differentiation with reduced hypertrophy marker expression in hyperoxia but have not been studied in physioxia. This study sought to… CONTINUE READING