Responses to Toll-like receptor ligands in children living in areas where schistosome infections are endemic.

@article{Kleij2004ResponsesTT,
  title={Responses to Toll-like receptor ligands in children living in areas where schistosome infections are endemic.},
  author={Desir{\'e}e van der Kleij and Anita H J van den Biggelaar and Yvonne C. M. Kruize and Kim Retra and Yvonne E. Filli{\'e} and M. J. W. M. Schmitz and Peter Gottfried Kremsner and Aloysius G. M. Tielens and Maria Yazdanbakhsh},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 6},
  pages={1044-51}
}
To study the effect of repeated challenge of the innate immune system with pathogen-associated molecular patterns, cytokine responses to schistosomal lipids and bacterial lipopolysaccharide (LPS) were analyzed in schoolchildren living in an area in Gabon where schistosomiasis, a helminth infection that is chronic in nature, is endemic. A schistosomal phosphatidylserine (PS) fraction containing the Toll-like receptor (TLR)-2 ligand lyso-PS stimulated the production of interleukin (IL)-8, IL-10… CONTINUE READING

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IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required Schistosome Infection and TLR Activation

  • TA Wynn, AW Cheever, ME Williams
  • JID
  • 2004
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