Responses to Central Na 1 and Ouabain Are Attenuated in Transgenic Rats Deficient in Brain Angiotensinogen


Studies with angiotensin (Ang) II type 1 receptor blockers suggest that the brain renin-angiotensin system contributes to sodium-induced sympathoexcitation and hypertension. To provide more specific evidence for the involvement of Ang II, locally produced in the brain, transgenic rats were used, which express an antisense RNA against angiotensinogen mRNA… (More)

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