Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-alpha.

@article{Royall1992ResponsesOV,
  title={Responses of vascular endothelial oxidant metabolism to lipopolysaccharide and tumor necrosis factor-alpha.},
  author={James A Royall and P D Gwin and Dale A. Parks and Bruce A. Freeman},
  journal={Archives of biochemistry and biophysics},
  year={1992},
  volume={294 2},
  pages={686-94}
}
Quantification of intracellular and extracellular levels and production rates of reactive oxygen species is crucial to understanding their contribution to tissue pathophysiology. We measured basal rates of oxidant production and the activity of xanthine oxidase, proposed to be a key source of O2- and H2O2, in endothelial cells. Then we examined the… CONTINUE READING