Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole.

  title={Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole.},
  author={Xiaowei Zhang and Markus Hecker and Amber R Tompsett and June-woo Park and Paul D. A. Jones and John L. Newsted and Doris Wai-Ting Au and Richard Kong and Rudolf Shiu Sun Wu and John Paul Giesy},
  journal={Environmental science & technology},
  volume={42 17},
Effects of two model imidazole-type fungicides, prochloraz (PCZ) and ketoconazole (KTC), on the hypothalamic-pituitary-gonadal (HPG) axis of the Japanese medaka (Oryzias latipe) [corrected] were examined by use of real time PCR (RT-PCR) array. Fourteen-week-old Japanese medaka were exposed for seven days to concentrations of PCZ or KTC from 3.0 to 300 microg/L Exposure [corrected] to KTC or PCZ caused significant reduction of fecundity of Japanese medaka and down-regulated expression of… CONTINUE READING


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