Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals.

@article{Mcgregor1988ResponsesOT,
  title={Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay: III. 72 coded chemicals.},
  author={Douglas Mcgregor and A Brown and Pamela Cattanach and Ian Edwards and Douglas McBride and Colin Riach and William J. Caspary},
  journal={Environmental and molecular mutagenesis},
  year={1988},
  volume={12 1},
  pages={
          85-154
        }
}
Seventy-two chemicals were tested for their mutagenic potential in the L5178Y tk+/- mouse lymphoma cell forward mutation assay, using procedures based upon those described by Clive and Spector (Mutat Res 44:269-278, 1975) and Clive et al. (Mutat Res 59:61-108, 1979). Cultures were exposed to the chemicals for 4 hr, then cultured for 2 days before plating in soft agar with or without trifluorothymidine (TFT), 3 micrograms/ml. The chemicals were tested at least twice. Significant responses were… 

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