Responses of renal and hepatic vitamin K dependent gamma-glutamyl carboxylase substrates to warfarin and vitamin K treatments.


A single intraperitoneal injection of warfarin (5 mg/kg) in the rat causes maximal accumulation of hepatic vitamin K dependent carboxylase substrate by 8 hr. In the kidney accumulation is slower with maximal amounts of the substrate appearing at about 16 hr. Vitamin K administered intravenously to warfarin-treated rats causes the complete disappearance of… (More)


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