Responses of rat suprachiasmatic nucleus neurons to substance P and glutamate in vitro.

@article{Shirakawa1994ResponsesOR,
  title={Responses of rat suprachiasmatic nucleus neurons to substance P and glutamate in vitro.},
  author={Tetsuo Shirakawa and Robert Y. Moore},
  journal={Brain research},
  year={1994},
  volume={642 1-2},
  pages={213-20}
}
The suprachiasmatic nucleus (SCN), a circadian pacemaker in the mammalian brain, receives photic information directly from the retina via the retinohypothalamic tract (RHT). Although the neurotransmitters of the RHT have not yet been identified, it is known that glutamate (Glu) and substance P (SP) are present in RHT axons. We report the responses of spontaneously firing SCN neurons to Glu and SP examined in isolated brain slices. 43% of the neurons show an excitatory response (an increase in… CONTINUE READING