Responses of limbic and extrapyramidal substance P systems to nicotine treatment

  title={Responses of limbic and extrapyramidal substance P systems to nicotine treatment},
  author={Mario E. Alburges and Paul S. Frankel and Amanda J. Hoonakker and Glen R. Hanson},
Neuropeptides are linked to the psychopathology of stimulants of abuse, principally through dopamine mechanisms. Substance P (SP) is one of these neuropeptides and is associated with both limbic and extrapyramidal dopaminergic pathways and likely contributes to the pharmacology of these stimulants. The effects of nicotine on these dopamine systems have also been extensively studied; however, its effects on the associated SP pathways have received little attention. In the present study, we… CONTINUE READING


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Highly Influential
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