Responses of human keratocytes to micro- and nanostructured substrates.

  title={Responses of human keratocytes to micro- and nanostructured substrates.},
  author={Ana Isabel Teixeira and Paul F. Nealey and Christopher John Murphy},
  journal={Journal of biomedical materials research. Part A},
  volume={71 3},
We have previously shown that human corneal epithelial cells respond to synthetic topographic features with dimensions similar to those found in the native human corneal basement membrane. Epithelial cells integrated inputs from substrate topography and soluble factors in the culture medium to generate alignment responses to substrate topographic anisotropies. Human keratocytes are the main cellular components of the stroma, the tissue that underlies the corneal epithelium. Here we report that… CONTINUE READING