Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors.

@article{Beningo2004ResponsesOF,
  title={Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors.},
  author={Karen A Beningo and Micah Dembo and Yu-li Wang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 52},
  pages={18024-9}
}
Fibroblasts in 2D cultures differ dramatically in behavior from those in the 3D environment of a multicellular organism. However, the basis of this disparity is unknown. A key difference is the spatial arrangement of anchored extracellular matrix (ECM) receptors to the ventral surface in 2D cultures and throughout the entire surface in 3D cultures. Therefore, we asked whether changing the topography of ECM receptor anchorage alone could invoke a morphological response. By using polyacrylamide… CONTINUE READING

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