Responses of ferret lower esophageal sphincter to 5-hydroxytryptamine: pathways and receptor subtypes.

Abstract

In urethananesthetized ferrets, basal lower esophageal sphincter pressure (LESP) was unaffected by the 5-hydroxytryptamine3 (5-HT3) receptor antagonist granisetron (0.5 mg/kg) or by greater splanchnic nerve section (GSX), but increased after bilateral vagotomy. Peripheral vagal nerve stimulation caused LES relaxation, often followed by a brief contraction… (More)

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Cite this paper

@article{Blackshaw1995ResponsesOF, title={Responses of ferret lower esophageal sphincter to 5-hydroxytryptamine: pathways and receptor subtypes.}, author={L Ashley Blackshaw and V Nisyrios and John Dent}, journal={The American journal of physiology}, year={1995}, volume={268 6 Pt 1}, pages={G1004-11} }