Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit.

@article{Milner2008ResponsesOE,
  title={Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit.},
  author={Richard S Milner and Stephanie Y Hung and Xiao-yun Wang and Greta I Berg and Maria Spatz and Gregory John del Zoppo},
  journal={Stroke},
  year={2008},
  volume={39 1},
  pages={191-7}
}
BACKGROUND AND PURPOSE Apposition of endothelial cells and astrocyte foot processes to the basal lamina matrix is postulated to underlie the cerebral microvessel permeability barrier. Focal cerebral ischemia induces rapid loss of select matrix-binding integrins from both cell compartments in the nonhuman primate. This study is the first to examine the conditions underlying integrin loss from these cell-types during ischemia in vitro and their relation to the changes in vivo. METHODS The… CONTINUE READING

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