Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology.

@article{Fracica1991ResponsesOB,
  title={Responses of baboons to prolonged hyperoxia: physiology and qualitative pathology.},
  author={Philip Fracica and Mark J. Knapp and Claude A. Piantadosi and Kazuki Takeda and William J. Fulkerson and R. Edward Coleman and Walter G. Wolfe and James D. Crapo},
  journal={Journal of applied physiology},
  year={1991},
  volume={71 6},
  pages={
          2352-62
        }
}
Cardiopulmonary responses to prolonged hyperoxia and their relationships to the development of lung pathology have not been fully characterized in primates. In this study, circulatory hemodynamics and pulmonary function, vascular permeability, and leukocyte sequestration were measured in male baboons after 100% O2 exposure and related to ultrastructural changes of lung injury by electron microscopy. Three groups of animals were exposed to 100% O2 in an exposure cage for 40, 66, and 80 h… CONTINUE READING
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