Responses Cyclophosphamide Treatment on Antitumor Immune Expression and Oncolysis in Combination with Low-Dose Effect of Adenovirus-Mediated Heat Shock Protein

Abstract

Heat shock proteins such as gp96 have the ability to chaperone peptides and activate antigen-presenting cells. In this study, we tested whether adenovirus-mediated overexpression of secreted or membrane-associated forms of gp96 in tumor cells would stimulate an antitumor immune response. Studies were carried out in C57Bl/6 mice bearing aggressively growing… (More)

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