Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?

@article{Cattaneo2012ResponseVT,
  title={Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?},
  author={Marco Cattaneo},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2012},
  volume={10 3},
  pages={
          327-36
        }
}
Clopidogrel is an antithrombotic prodrug, whose active metabolite inhibits platelet function by irreversibly binding to the platelet receptor for adenosine diphosphate, P2Y(12). Wide inter-individual variability of response to clopidogrel has been reported in several studies: a significant proportion of treated patients (about one-third) exhibit a suboptimal inhibition of platelet function. Genetic and environmental factors that influence the absorption and/or the extent of metabolism of… CONTINUE READING
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